{"id":1435,"date":"2022-05-04T10:02:06","date_gmt":"2022-05-04T08:02:06","guid":{"rendered":"https:\/\/www.toulouse-white-biotechnology.com\/insights\/actualites\/actualite\/yscript-the-messenger-rna-project-at-twb\/"},"modified":"2026-03-16T09:31:46","modified_gmt":"2026-03-16T08:31:46","slug":"yscript-the-messenger-rna-project-at-twb","status":"publish","type":"post","link":"https:\/\/www.toulouse-white-biotechnology.com\/en\/insights\/blog\/news\/yscript-the-messenger-rna-project-at-twb\/","title":{"rendered":"Engineering yeast for mRNA production: TWB is partner of the european project Yscript"},"content":{"rendered":"<strong>Launched in April 2022, the Yscript project aims to develop a tailor-made yeast-based messenger RNA (mRNA) factory platform for large-scale and cost-effective manufacturing of mRNA therapeutics. Selected by the European Union as part of Horizon Europe, the Yscript consortium brings together eight partners from 5 countries: CNRS, TWB INRAE (France); UAVR, UBI (Portugal); TRON gGmbH, EURICE (Germany); IBCH PAS (Poland); BIASEP (Slovenia). It is led by Prof Chantal Pichon, from Centre de Biophysique Mol\u00e9culaire of CNRS and University of Orl\u00e9ans. <\/strong>\n\n<p>&quot;The project will be a gamechanger in the fight against many diseases&quot; and &quot; the development of a specific mRNA-bioproduction and purification process in yeast would be groundbreaking&quot; says Prof. Chantal Pichon. The overall budget allocated to the project is \u20ac3,400,000.<\/p>\n\n<h2 class=\"wp-block-heading\"><strong>The yeast cell factory for mRNA bioproduction<\/strong><\/h2>\n\n<p>Yeast cells are known to be safe for human applications and are already used in the production of pharmaceuticals, among other applications. However, yeast has never been used in the production of messenger RNA for therapeutic purposes. Currently, production is performed by in-vitro synthesis with a complex supply chain and an expensive purification process. The scientific challenge is to produce mRNA of a gene of interest on demand and to separate this specific mRNA from other mRNAs in yeast. The project attempts to do this by assembling mRNA-of-interest in specialized compartments, from where it could be specifically purified.\r\n\r\n<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-13989 size-full\" src=\"https:\/\/www.toulouse-white-biotechnology.com\/app\/uploads\/2022\/05\/bioproduction_process_yscript-1.png\" alt=\"Yscript bioproduction process\" width=\"1803\" height=\"468\">\r\n\r\n\u00a0<\/p>\n\n<h2 class=\"wp-block-heading\"><strong>TWB &amp; yeast bioprocess development<\/strong><\/h2>\n\n<p>Over the next 3 years, Yscript will focus on two objectives:<\/p>\n\n<ul class=\"wp-block-list\">\r\n \t<li>The development of a robust and scalable yeast-bioprocess for the production of different lengths of mRNA.<\/li>\r\n<\/ul>\n\n<ul class=\"wp-block-list\">\r\n \t<li>The design of innovative and cost-effective extraction and purification processes for bio produced mRNA.<\/li>\r\n<\/ul>\n\n<p>TWB will work on the first objective in order to improve the robustness and develop the scale-up of the proof of concept.\r\n\r\nThe project has the potential to provide Europe with a cost-effective approach to defend itself against future infection outbreaks, but also to expand its arsenal to treat chronic diseases, which are on the rise due to population aging. Chantal Pichon is convinced that &quot;Yscript will promote the development of affordable and accessible mRNA-based therapies for the well-being and health of citizens around the world. Thus, TWB is contributing to a project that will have a positive impact not only on health, but also on the economy and society.<\/p>\n\n<em><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-13985 size-full\" src=\"https:\/\/www.toulouse-white-biotechnology.com\/app\/uploads\/2022\/05\/eu-1.jpg\" alt=\"European Innovation Council\" width=\"150\" height=\"63\">Yscript has received funding from the European Innovation Council (EIC) under grant agreement No 101047214. The EIC receives support from the European Union\u2019s Horizon Europe research and innovation programme.<\/em>\n\n<p>\u00a0<\/p>\n\n<ul class=\"wp-block-list\">\r\n \t<li><a href=\"https:\/\/www.yscript.eu\/\">Yscript<\/a> project website.<\/li>\r\n<\/ul>\n\n<sup>1<\/sup>\n\n<strong>Messenger RNA<\/strong>\n\n<p>, messenger ribonucleic acid or mRNA is an intermediate ribonucleic acid molecule (present in living beings and certain viruses), consisting of a transient copy of a portion of DNA. mRNA corresponds to one or more genes of a biological organism.<\/p>\n\n<sup>2<\/sup>\n\n<strong> GRAS<\/strong>\n\n<p>\u00a0: \u2018\u2019Generally Recognized As Safe\u2019\u2019.<\/p>","protected":false},"excerpt":{"rendered":"<p>Launched in April 2022, the Yscript project aims to develop a tailor-made yeast-based messenger RNA (mRNA) factory platform for large-scale and cost-effective manufacturing of mRNA therapeutics. Selected by the European Union as part of Horizon Europe, the Yscript consortium brings together eight partners from 5 countries: CNRS, TWB INRAE (France); UAVR, UBI (Portugal); TRON gGmbH, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1439,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_schema_org_content_json":"","footnotes":""},"categories":[5,1],"tags":[],"class_list":["post-1435","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualite","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/1435","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/comments?post=1435"}],"version-history":[{"count":1,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/1435\/revisions"}],"predecessor-version":[{"id":1438,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/1435\/revisions\/1438"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/media\/1439"}],"wp:attachment":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/media?parent=1435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/categories?post=1435"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/tags?post=1435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}