{"id":3506,"date":"2016-09-29T15:12:48","date_gmt":"2016-09-29T13:12:48","guid":{"rendered":"https:\/\/www.toulouse-white-biotechnology.com\/insights\/actualites\/actualite\/biologie-synthetique-chez-microalgues\/"},"modified":"2026-03-16T13:52:38","modified_gmt":"2026-03-16T12:52:38","slug":"biologie-synthetique-chez-microalgues","status":"publish","type":"post","link":"https:\/\/www.toulouse-white-biotechnology.com\/insights\/blog\/news\/biologie-synthetique-chez-microalgues\/","title":{"rendered":"Biologie synth\u00e9tique chez les microalgues"},"content":{"rendered":"
\"algues\"<\/figure>\n\nhttp:\/\/www.lisbp.fr\/fr\/la_recherche\/biologie-synthetique-chez-les-microalgues.html<\/a>\n\n

Sa mission\u00a0:<\/h2>\n\n

Cr\u00e9er un ch\u00e2ssis microalgue pour la biologie de synth\u00e8se. Placer les microalgues parmi les acteurs cl\u00e9s de la transition vers la bio\u00e9conomie.<\/p>\n\n

Mots cl\u00e9s\u00a0:<\/h2>\n\n

Edition de g\u00e9nomes- Ing\u00e9nierie m\u00e9tabolique-Biologie de synth\u00e8se-microalgues<\/p>\n\n

Responsable\u00a0:<\/h2>\n\nFayza Daboussi<\/strong>\n\n

– Directrice de Recherche INRA – fayza.daboussi@insa-toulouse.fr\r\nEquipe cr\u00e9\u00e9e en 2015<\/p>\n\n

Effectifs \u00e9quipe\u00a0en 2016\u00a0: 6<\/h2>\n\n

Enseignants et chercheurs\u00a0: 1\r\nIng\u00e9nieurs\u00a0: 1\r\nAssistants ing\u00e9nieurs et techniciens\u00a0: 0\r\nPost-doctorants et doctorants\u00a0: 4<\/p>\n\n

Axes\u00a0th\u00e9matiques :<\/h2>\n\n
    \r\n\t
  • Axe 1\u00a0: D\u00e9velopper des m\u00e9thodologies d\u2019ing\u00e9nierie des g\u00e9nomes<\/li>\r\n\t
  • Axe 2\u00a0: Appr\u00e9hender le probl\u00e8me de l\u2019instabilit\u00e9 g\u00e9n\u00e9tique des souches soumises \u00e0 un processus d\u2019industrialisation<\/li>\r\n\t
  • Axe 3\u00a0: Re-construire le m\u00e9tabolisme des lipides<\/li>\r\n\t
  • Axe 4\u00a0: Produire de nouvelles classes de carot\u00e9no\u00efdes<\/li>\r\n\t
  • Axe 5\u00a0: D\u00e9river de nouvelles voies m\u00e9taboliques<\/li>\r\n<\/ul>\n\n

    Activit\u00e9s principales\u00a0:<\/h2>\n\n
      \r\n\t
    • Optimiser l\u2019activit\u00e9 et la sp\u00e9cificit\u00e9 des outils d\u2019ing\u00e9nierie de g\u00e9nome<\/li>\r\n\t
    • R\u00e9guler et contr\u00f4ler l\u2019expression des g\u00e8nes contr\u00f4lant une voie m\u00e9tabolique artificielle<\/li>\r\n\t
    • Augmenter les connaissances sur le m\u00e9tabolisme cellulaire<\/li>\r\n\t
    • D\u00e9velopper et am\u00e9liorer le potentiel m\u00e9tabolique des microalgues pour la production de mol\u00e9cules d\u2019int\u00e9r\u00eat<\/li>\r\n<\/ul>\n\n

      Mod\u00e8les\u00a0de recherche :<\/h2>\n\n
        \r\n\t
      • Microalgue\u00a0: la diatom\u00e9e Phaeodactylum tricornutum<\/em><\/li>\r\n\t
      • Levures\u00a0: Saccharomyces cerevisiae, Yarrowia lipolytica<\/em><\/li>\r\n<\/ul>\n\n

        Domaines d\u2019application\u00a0et produits cibles :<\/h2>\n\n

        Production de mol\u00e9cules d\u2019int\u00e9r\u00eat pour les secteurs de\u00a0:<\/p>\n\n

          \r\n\t
        • l\u2019\u00e9nergie (lipides)<\/li>\r\n\t
        • la chimie (acides gras, biopolym\u00e8res)<\/li>\r\n\t
        • la sant\u00e9 (pigments, prot\u00e9ines).<\/li>\r\n<\/ul>\n\n

          Technologies, techniques, outils sp\u00e9cifiques\u00a0:<\/h2>\n\n
            \r\n\t
          • Modifications g\u00e9n\u00e9tiques cibl\u00e9es (CRISPR\/Cas9, TALE nucleases\u2026)<\/li>\r\n\t
          • Outils et m\u00e9thodologies pour moduler l\u2019expression des g\u00e8nes<\/li>\r\n\t
          • Ing\u00e9nierie m\u00e9tabolique<\/li>\r\n<\/ul>\n\n

            Publications et brevets significatifs :<\/h2>\n\n
              \r\n\t
            • Daboussi F<\/strong>, Leduc S, Mar\u00e9chal A, Dubois G, Guyot V, Perez-Michaut C, Amato A, Falciatore A, Juillerat A, Beurdeley M, Voytas DF, Cavarec L, Duchateau P. (2014) Genome engineering empowers the diatom Phaeodactylum tricornutum for biotechnology. Nat Commun. 29; 5: 3831.<\/li>\r\n\t
            • WO2014\/076571A2: Method for targeted modification of algae genome. Duchateau P, Daboussi F<\/strong>.<\/li>\r\n\t
            • WO\/2014\/207043 Modified diatoms for biofuel production. Duchateau P, Daboussi F<\/strong>, Sourdive D & Epinat JC<\/li>\r\n<\/ul>\n\n

              Projets pr\u00e9comp\u00e9titifs TWB:<\/h2>\n\n
                \r\n\t
              • XANTHALG<\/strong> – Biosynth\u00e8se de xanthophylles : plateforme pour mol\u00e9cules th\u00e9rapeutiques<\/li>\r\n\t
              • CRISPY<\/strong> – Plateforme CRISPR pour l’ing\u00e9nierie de Yarrowia lipolytica<\/li>\r\n<\/ul>","protected":false},"excerpt":{"rendered":"

                http:\/\/www.lisbp.fr\/fr\/la_recherche\/biologie-synthetique-chez-les-microalgues.html Sa mission\u00a0: Cr\u00e9er un ch\u00e2ssis microalgue pour la biologie de synth\u00e8se. Placer les microalgues parmi les acteurs cl\u00e9s de la transition vers la bio\u00e9conomie. Mots cl\u00e9s\u00a0: Edition de g\u00e9nomes- Ing\u00e9nierie m\u00e9tabolique-Biologie de synth\u00e8se-microalgues Responsable\u00a0: Fayza Daboussi – Directrice de Recherche INRA – fayza.daboussi@insa-toulouse.fr Equipe cr\u00e9\u00e9e en 2015 Effectifs \u00e9quipe\u00a0en 2016\u00a0: 6 Enseignants et chercheurs\u00a0: […]<\/p>\n","protected":false},"author":1,"featured_media":3532,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_schema_org_content_json":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-3506","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/3506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/comments?post=3506"}],"version-history":[{"count":1,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/3506\/revisions"}],"predecessor-version":[{"id":3531,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/3506\/revisions\/3531"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/media\/3532"}],"wp:attachment":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/media?parent=3506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/categories?post=3506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/tags?post=3506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}