{"id":3545,"date":"2016-09-29T15:42:06","date_gmt":"2016-09-29T13:42:06","guid":{"rendered":"https:\/\/www.toulouse-white-biotechnology.com\/insights\/actualites\/actualite\/synthetic-biology-in-microalgae\/"},"modified":"2026-03-16T13:52:40","modified_gmt":"2026-03-16T12:52:40","slug":"synthetic-biology-in-microalgae","status":"publish","type":"post","link":"https:\/\/www.toulouse-white-biotechnology.com\/en\/insights\/blog\/news\/synthetic-biology-in-microalgae\/","title":{"rendered":"Synthetic biology in microalgae"},"content":{"rendered":"
\"algues\"<\/figure>\n\nhttp:\/\/www.lisbp.fr\/en\/research\/synthetic-biology-in-microalgea.html<\/a>\n\n

Its mission:<\/h2>\n\n

Creating a micro-alga chassis for synthetic biology. Placing micro-algae among the key actors of the transition to bioeconomy.<\/p>\n\n

Key words:<\/h2>\n\n

Genome editing- Metabolic engineering- Synthesis biology- Micro-algae<\/p>\n\n

Person in charge:<\/h2>\n\nFayza Daboussi<\/strong>\n\n

– Director of research INRA – fayza.daboussi@insa-toulouse.fr\r\nTeam created in 2015<\/p>\n\n

Team numbers in 2016: 6<\/h2>\n\n

Teachers and researchers: 1\r\nEngineers: 1\r\nAssistant engineers and technicians: 0\r\nPost-doctoral and doctoral students: 4<\/p>\n\n

Thematic axes:<\/h2>\n\n
    \r\n\t
  • Axis 1: Developing methodologies for genome engineering<\/li>\r\n\t
  • Axis 2: Understanding the problem of genetic instability of strains subject to an industrialization process<\/li>\r\n\t
  • Axis 3: Re-constructing the lipid metabolism<\/li>\r\n\t
  • Axis 4: Producing new classes of carotenoids<\/li>\r\n\t
  • Axe 5: Deriving new metabolic pathways<\/li>\r\n<\/ul>\n\n

    Main activities:<\/h2>\n\n
      \r\n\t
    • Optimizing the activity and specificity of genome engineering tools<\/li>\r\n\t
    • Regulating and controlling the expression of genes controlling an artificial metabolic pathway<\/li>\r\n\t
    • Increasing knowledge on cellular metabolism<\/li>\r\n\t
    • Developing and improving the metabolic potential of micro-algae for producing molecules of interest<\/li>\r\n<\/ul>\n\n

      Research models:<\/h2>\n\n
        \r\n\t
      • Micro-algae: the diatom Phaeodactylum tricornutum<\/em><\/li>\r\n\t
      • Yeasts: Saccharomyces cerevisiae, Yarrowia lipolytica<\/em><\/li>\r\n<\/ul>\n\n

        Fields of application and target products:<\/h2>\n\n

        Production of molecules of interest for the following sectors:<\/p>\n\n

          \r\n\t
        • energy (lipids)<\/li>\r\n\t
        • chemistry (fatty acids, biopolymers)<\/li>\r\n\t
        • health (pigments, proteins).<\/li>\r\n<\/ul>\n\n

          Technologies, techniques, specific tools:<\/h2>\n\n
            \r\n\t
          • Targeted genetic modifications (CRISPR\/Cas9, TALE nucleases, etc.)<\/li>\r\n\t
          • Tools and methodologies for modulating gene expression<\/li>\r\n\t
          • Metabolic engineering<\/li>\r\n<\/ul>\n\n

            Significant publications and patents:<\/h2>\n\n
              \r\n\t
            • Daboussi F<\/strong>, Leduc S, Mar\u00e9chal A, Dubois G, Guyot V, Perez-Michaut C, Amato A, Falciatore A, Juillerat A, Beurdeley M, Voytas DF, Cavarec L, Duchateau P. (2014) Genome engineering empowers the diatom Phaeodactylum tricornutum for biotechnology. Nat Commun. 29; 5: 3831.<\/li>\r\n\t
            • WO2014\/076571A2: Method for targeted modification of algae genome. Duchateau P, Daboussi F<\/strong>.<\/li>\r\n\t
            • WO\/2014\/207043 Modified diatoms for biofuel production. Duchateau P, Daboussi F<\/strong>, Sourdive D & Epinat JC<\/li>\r\n<\/ul>\n\n

              TWB precompetitive projects:<\/h2>\n\n
                \r\n\t
              • XANTHALG<\/strong> – Biosynthesis of xanthophylls: platform for therapeutic molecules<\/li>\r\n\t
              • CRISPY<\/strong> – CRISPR platform for the engineering of Yarrowia lipolytica<\/li>\r\n<\/ul>","protected":false},"excerpt":{"rendered":"

                http:\/\/www.lisbp.fr\/en\/research\/synthetic-biology-in-microalgea.html Its mission: Creating a micro-alga chassis for synthetic biology. Placing micro-algae among the key actors of the transition to bioeconomy. Key words: Genome editing- Metabolic engineering- Synthesis biology- Micro-algae Person in charge: Fayza Daboussi – Director of research INRA – fayza.daboussi@insa-toulouse.fr Team created in 2015 Team numbers in 2016: 6 Teachers and researchers: 1 […]<\/p>\n","protected":false},"author":1,"featured_media":3577,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_schema_org_content_json":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-3545","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/3545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/comments?post=3545"}],"version-history":[{"count":1,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/3545\/revisions"}],"predecessor-version":[{"id":3564,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/3545\/revisions\/3564"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/media\/3577"}],"wp:attachment":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/media?parent=3545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/categories?post=3545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/tags?post=3545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}