{"id":3701,"date":"2016-07-04T15:56:16","date_gmt":"2016-07-04T13:56:16","guid":{"rendered":"https:\/\/www.toulouse-white-biotechnology.com\/insights\/actualites\/actualite\/biochip-and-bionanotechnology\/"},"modified":"2026-03-16T13:52:46","modified_gmt":"2026-03-16T12:52:46","slug":"biochip-and-bionanotechnology","status":"publish","type":"post","link":"https:\/\/www.toulouse-white-biotechnology.com\/en\/insights\/blog\/news\/biochip-and-bionanotechnology\/","title":{"rendered":"Biochip and Bionanotechnology"},"content":{"rendered":"<a href=\"http:\/\/www.lisbp.fr\/en\/research\/ead2.html\" target=\"_blank\">http:\/\/www.lisbp.fr\/en\/research\/ead2.html<\/a>\n\n<h2 class=\"wp-block-heading\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-5264\" src=\"https:\/\/www.toulouse-white-biotechnology.com\/app\/uploads\/2016\/07\/contenu-newsletter-10_fren_2016-06-30.docx-300x300-2.jpg\" alt=\"Contenu Newsletter 10_FR+EN_2016-06-30.docx\" width=\"300\" height=\"300\">Its mission<\/h2>\n\n<p>Team of multidisciplinary research, certified ISO 9001:2008 since 2013, which develops tools for diagnostics, interaction between biomolecules, and analyses of microbial biodiversity.<\/p>\n\n<h2 class=\"wp-block-heading\">Key words<\/h2>\n\n<p>Transcriptomics, genomics, interaction, diagnosis, biochips, sequencing<\/p>\n\n<h2 class=\"wp-block-heading\">Person in charge<\/h2>\n\n<strong>V\u00e9ronique Le Berre<\/strong>\n\n<p>\u2013 Charg\u00e9e de recherche CNRS<\/p>\n\n<a href=\"mailto:veronique.leberre@insa-toulouse.fr\" target=\"_blank\">veronique.leberre@insa-toulouse.fr<\/a>\n\n<h2 class=\"wp-block-heading\">Team numbers in 2016: 10<\/h2>\n\n<p>Teachers and researchers: 1 \/ engineers: 6 \/ assistant engineers and technicians: 0 \/ post-doctoral and doctoral students: 3<\/p>\n\n<h2 class=\"wp-block-heading\">Thematic axes<\/h2>\n\n<ul class=\"wp-block-list\">\r\n\t<li><strong>AXIS 1<\/strong>: Development of diagnostic tools<\/li>\r\n\t<li><strong>AXIS 2<\/strong>: Study of the interactions between biomolecules<\/li>\r\n\t<li><strong>AXIS 3<\/strong>: Genetic adaptation and biodiversity<\/li>\r\n\t<li><strong>AXIS 4<\/strong>: Development of new applications for NGS (ChIP-exo, single cell, CLIP seq, etc.) and associated statistics and computer tools<\/li>\r\n<\/ul>\n\n<h2 class=\"wp-block-heading\">Main activities<\/h2>\n\n<ul class=\"wp-block-list\">\r\n\t<li>Design of new generations of biochips for diagnosis (food-borne pathogens, toxic algae, breast cancer, allergies, glycosyl hydrolases involved in the degradation of the lignocellulosic biomass, etc.).<\/li>\r\n\t<li>Study of microbial biodiversity through sequencing and methods development<\/li>\r\n\t<li>Analysis of the interactions between biomolecules and the molecular characterisation of the role of the nucleoid in the mechanism of segregation of F plasmid in E. coli through SPRi and NGS approaches.<\/li>\r\n<\/ul>\n\n<h2 class=\"wp-block-heading\">Research models<\/h2>\n\n<p>Essentially diverse micro-organisms (bacteria, micro-algae, yeast, etc.) but also of higher eukaryotes (man, animals, plants, etc.) in certain collaborative projects<\/p>\n\n<h2 class=\"wp-block-heading\">Fields of application and target products<\/h2>\n\n<ul class=\"wp-block-list\">\r\n\t<li>Agri-food: &#8220;SECURIDIAL&#8221; biochip for the detection of food-borne pathogens,<\/li>\r\n\t<li>Health: &#8220;INNODIAG&#8221; biochip for the identification of a gene signature in the context of breast cancer,<\/li>\r\n\t<li>Food: &#8220;DIAGALA&#8221; biochip for the diagnosis of food allergies,<\/li>\r\n\t<li>Environment: &#8220;PHYTOCHIP&#8221; biochip for the detection of toxic micro-algae,<\/li>\r\n\t<li>Renewable energies: &#8220;CAZYCHIP&#8221; biochip for the analysis of the expression of the glycosyl hydrolases (GH) involved in the degradation of plant biomass.<\/li>\r\n<\/ul>\n\n<h2 class=\"wp-block-heading\">Technologies, techniques, specific tools<\/h2>\n\n<ul class=\"wp-block-list\">\r\n\t<li>Biochips (DNA or protein chips): Agilent, Affymetrix, custom chips<\/li>\r\n\t<li>NGS sequencing<\/li>\r\n\t<li>Microfluidics for the analysis of individual clones<\/li>\r\n\t<li>Probe design<\/li>\r\n\t<li>Bioinformatic analyses<\/li>\r\n<\/ul>\n\n<p>For the realisation of some of its projects, the team also enjoys the support of the equipment available at the adjoining GeT-Biopuces platform (<\/p>\n\n<a href=\"http:\/\/www.lisbp.fr\/fr\/plateformes_technologiques\/transcriptome_biopuces.html\" target=\"_blank\">http:\/\/www.lisbp.fr\/fr\/plateformes_technologiques\/transcriptome_biopuces.html<\/a>\n\n<p>).<\/p>\n\n<h2 class=\"wp-block-heading\">Significant publications and patents<\/h2>\n\n<ul class=\"wp-block-list\">\r\n\t<li>Pillet F.; Sanchez A.; Trevisiol E.; Severac M., Bouet J.Y.; Anton Leberre V. (2013) Dendrimer functionalization of gold surface improves the measurement of Protein-DNA interactions by Surface Plasmon Resonance imaging. Biosensors &amp; Bioelectronics. (2013), vol 43 pp. 148-154<\/li>\r\n\t<li>Cyntia R. Flores-Ju\u00e1rez, V\u00e9ronique Anton Leberre, Emmanuelle Tr\u00e9visiol, Eva Gonz\u00e1lez-Jasso1, and Reynaldo C. Pless (2014) Hybridisation of N4-methylcytosine-containing amplicons on DNA microarrays. Journal of Biotechnology 189 (2014) 143\u2013149<\/li>\r\n\t<li>Tatiana Kempowsky-Hamon, Carine Valle, Magali Lacroix-Triki, Lyamine Hedjazi, Sophie Lamarre, Lidwine Trouilh, Delphine Labourdette, Laurence Puydenus Roger, Loubna Mhamdi, Florence Dalenc, Thomas Filleron, Gilles Favre, Jean M Fran\u00e7ois, Marie V Le Lann and V\u00e9ronique Anton Leberre. (2015) Fuzzy logic selection as a new reliable tool to identify molecular grade signatures in breast cancer \u2013 the INNODIAG study. BMC Medical Genomics 2015, 8:3<\/li>\r\n\t<li>Charlotte Noyer; Anne Abot; Lidwine Trouilh; Veronique Anton Leberre; Catherine Dreanno (2015) Phytochip: Development of a DNA-microarray for rapid and accurate identification of Pseudo-nitzschia spp and other harmful algal species. Journal of Microbiological Method. available online: 10-MAR-2015 &#8211; 112:55-66.<\/li>\r\n\t<li>Chassaing, N., Davis, E. E., McKnight, K. L., Niederriter, A. R., Causse, A., David, V., Desmains, A., Lamarre, S., Vincent-Delorme C, Pasquier L, Coubes C, Lacombe D, Rossi M, Dufier JL, Dollfus H1, Kaplan J, Katsanis N, Etchevers HC, Faguer S, Calvas P Coubes, C. (2016). Targeted resequencing identifies PTCH1 as a major contributor to ocular developmental anomalies and extends the SOX2 regulatory network. Genome Research Apr;26(4):474-85<\/li>\r\n<\/ul>\n\n<h2 class=\"wp-block-heading\">Precompetitive projects<\/h2>\n\n<strong>GENOFLUID<\/strong>\n\n<p>&#8211; Innovative mini-fluidic devices for the on-line pseudo-clonal analysis of the metabolism and genotype-phenotype relations within micro-organisms<\/p>","protected":false},"excerpt":{"rendered":"<p>http:\/\/www.lisbp.fr\/en\/research\/ead2.html Its mission Team of multidisciplinary research, certified ISO 9001:2008 since 2013, which develops tools for diagnostics, interaction between biomolecules, and analyses of microbial biodiversity. Key words Transcriptomics, genomics, interaction, diagnosis, biochips, sequencing Person in charge V\u00e9ronique Le Berre \u2013 Charg\u00e9e de recherche CNRS veronique.leberre@insa-toulouse.fr Team numbers in 2016: 10 Teachers and researchers: 1 \/ [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3737,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_schema_org_content_json":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-3701","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/3701","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/comments?post=3701"}],"version-history":[{"count":1,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/3701\/revisions"}],"predecessor-version":[{"id":3731,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/posts\/3701\/revisions\/3731"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/media\/3737"}],"wp:attachment":[{"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/media?parent=3701"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/categories?post=3701"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.toulouse-white-biotechnology.com\/en\/wp-json\/wp\/v2\/tags?post=3701"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}