D050c8d3a121a8c7c5750dce6da824154f11c809

Our expertise

TWB combine des technologies avancées à une excellence scientifique reconnue afin d’intervenir de manière intégrée à chaque étape du continuum de l’innovation et d’accompagner efficacement les projets de R&D. Son offre repose sur quatre domaines d’expertise interopérables, permettant à la fois d’accélérer les développements, de réduire les risques ainsi que les coûts associés.

Nous croyons que les biotechnologies qui visent à développer des voies de production performantes et plus respectueuses de la nature représentent un pilier du monde durable à construire.
Dans cette perspective, les travaux s’inscrivent dans une logique de transfert industriel, fondée sur des méthodes robustes, rigoureusement validées et directement exploitables en environnement pré-industriel. Les modalités de collaboration sont adaptées grâce à des dispositifs contractuels flexibles, ajustés aux besoins spécifiques et au niveau d’innovation des projets.

De l’ingénierie métabolique et génomique à la fermentation, TWB déploie une approche globale et responsable, intégrant pleinement les dimensions environnementales, économiques et éthiques.

Fields of Application

Reducing the environmental impact of industry by addressing product, process, and industrialization challenges.

Chemistry

Industrial biotechnology is transforming chemistry by offering sustainable alternatives to traditional processes, enabling the production of valuable molecules using microorganisms or enzymes.

TWB supports these developments through the versatility of its expertise and its analytical platforms in chemistry and cellular characterization equipped with advanced technologies.

Attentive to the needs of the chemistry sector, TWB contributes to the emergence of greener, more efficient, and industrially scalable chemistry.

Transforming industrial effluents into bio-based molecules
Reducing the use of toxic chemical solvents and catalysts through enzymes
Producing at large scale molecules that are difficult to extract
Securing fragile supply chains (plant-based extraction) or reducing their environmental impact

Cosmetics

To meet consumers’ expectations for naturalness, industrial biotechnology is transforming the cosmetics industry by offering sustainable and innovative alternatives to conventional ingredients and processes. It enables the production of valuable active ingredients using microorganisms or enzymes, while improving their performance, naturalness, and traceability.

TWB supports these developments through its multidisciplinary approach covering the entire value chain.

Producing bio-based active ingredients as alternatives to natural extracts or petrochemical ingredients
Improving the stability, functionality, and bioavailability of cosmetic actives
Optimizing the fermentation of a natural ingredient at a competitive cost
Securing the supply of sensitive ingredients and reducing the environmental impact of supply chains
Replacing controversial chemical substances with biological solutions

Health

Industrial biotechnology contributes to the development of innovative solutions for healthcare. It enables the production of therapeutic biomolecules and active ingredients through manufacturing pathways that support safe, controlled, and reproducible processes.

TWB therefore supports innovation in healthcare, from concept to proof of feasibility, and mobilizes its platforms to accelerate the development and scale-up of innovative solutions that strengthen French bioproduction sovereignty and healthcare innovation.

Producing complex therapeutic molecules
Developing biomarkers for diagnostics
Supporting sovereignty in therapeutic bioproduction

Nutrition

Today, industrial biotechnology is innovating in the production of food and nutritional ingredients, improving the functionality, safety, and traceability of products.

TWB supports the development of strains, processes, and pilot-scale production tailored to the needs of the sector.

Improving properties (taste, stability, bioactivity) through fermentation
Developing bio-based ingredients to help increase livestock productivity
Contributing to the security of food supply chains through new traceability markers
Producing bio-based dietary supplements for the nutraceutical sector

Nous contacter

Energy

The production of renewable energy is at the heart of addressing humanity’s impact on the environment. Industrial biotechnology makes it possible to convert biomass into biofuels and energy molecules. These processes help reduce dependence on fossil resources.

TWB works on optimizing strains and processes to improve yields and industrial viability.
In doing so, it actively contributes to the energy transition.

Treating or valorizing industrial effluents and organic waste as energy
Optimizing industrial bioprocesses to reduce the carbon footprint using microorganisms or enzymes

Agriculture and Environment

Industrial biotechnology provides sustainable solutions for agriculture and soil health. By developing biofertilizers, biostimulants, and biocontrol solutions, these approaches help reduce the use of chemical inputs and the environmental and health impacts of agricultural practices, within a “One Health” approach. They therefore support the development of more sustainable and resilient agricultural systems.

TWB supports the design and optimization of microorganisms and processes tailored to agricultural applications.

Producing peptides intended for biocontrol
Driving the natural evolution of microorganisms that provide ecosystem services in soils

Scientific and technological expertise

Twb Laboratoire Ingenierie De Souches Access

Strain engineering

The platform is composed of a fleet of robots and high-throughput equipment that automate several key steps and provide solutions to accelerate screening operations and variant generation. The service conducts genetic and metabolic engineering projects, as well as synthetic biology, across a wide range of microbial domains: bacteria, fungi, microalgae, and yeasts, including both conventional and non-conventional chassis.

Bioprocesses

Thanks to a fleet of instrumented conventional bioreactors ranging from 1 mL to 300 L, combined with automated systems enabling parallel fermentation and micro-fermentation, this service allows the study, design, and optimization of enzymatic and microbial processes (pure cultures or consortia).

Analytical chemistry

The platform implements advanced analytical chemistry methods enabling the qualitative exploration and precise quantification of compounds present in complex fermentation matrices. This service provides advanced analytical solutions and dedicated expertise for the characterization of reaction media resulting from fermentation, in order to accelerate the development of bioprocesses.

Cellular characterization

Specialized in microbial cytometry and equipped with state-of-the-art instruments, TWB’s cytometry platform offers innovative multiparametric approaches including single-cell analysis, high-purity cell sorting, viability monitoring, and advanced spectral cytometry. The platform supports bioprocess development from variant screening to fermentation monitoring at all scales.