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Our expertise

TWB combines advanced technologies with recognized scientific excellence to provide integrated support at every stage of the innovation continuum and effectively assist R&D projects. Its offering is based on four interconnected areas of expertise, enabling the acceleration of development while reducing both risks and associated costs.

We believe that biotechnologies aimed at developing high-performance production pathways that are more environmentally friendly represent a cornerstone of the sustainable world we are building.
With this in mind, our work is guided by a focus on industrial transfer, based on robust methods that are rigorously validated and directly applicable in pre-industrial settings. Collaboration terms are tailored through flexible contractual arrangements, adapted to the specific needs and level of innovation of each project.

From metabolic and genomic engineering to fermentation, TWB takes a comprehensive and responsible approach, fully integrating environmental, economic, and ethical considerations.

Scientific and technological expertise

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Strain engineering

The platform has a range of high-throughput equipment dedicated to handling DNA sequences and microorganisms in miniaturised formats. Its activities help to accelerate the creation of tailored variant libraries and provide effective solutions for screening them.

The department carries out projects in genetic and metabolic engineering, as well as synthetic biology.

Bioprocesses

With a range of instrumented bioreactors from 1 mL to 300 L, enabling parallel fermentation and micro-fermentation, this service facilitates the study, design and optimisation of enzymatic and microbial processes.

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Analytical chemistry

The platform employs state-of-the-art analytical chemistry methods to enable the qualitative analysis and quantification of compounds present in fermentation samples (culture broths, cell pellets, supernatants, etc.).

This service utilises cutting-edge analytical systems and specialist expertise in the characterisation of fermentation reaction media in order to accelerate the development of bioprocesses.

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Cellular characterization

Specialising in flow cytometry and equipped with state-of-the-art equipment, TWB’s cell characterisation platform offers innovative multi-parametric approaches at the single-cell level.

It is dedicated to the analysis and sorting of microorganisms, supporting research and innovation projects in industrial biotechnology by providing high-performance tools to characterise, monitor and select the most efficient cell populations.

The platform is involved at various stages of bioprocess development, from the screening of variants to the monitoring of fermentations at all scales, as well as the quality control of produced batches and technology transfer.

Fields of Application

Reducing the environmental impact of industry by addressing product, process, and industrialization challenges.

Chemistry

Industrial biotechnology is transforming chemistry by offering sustainable alternatives to traditional processes, enabling the production of valuable molecules using microorganisms or enzymes.

TWB supports these developments through the versatility of its expertise and its analytical platforms in chemistry and cellular characterization equipped with advanced technologies.

Attentive to the needs of the chemistry sector, TWB contributes to the emergence of greener, more efficient, and industrially scalable chemistry.

Transforming industrial effluents into bio-based molecules
Reducing the use of toxic chemical solvents and catalysts through enzymes
Producing at large scale molecules that are difficult to extract
Securing fragile supply chains (plant-based extraction) or reducing their environmental impact

Cosmetics

To meet consumers’ expectations for naturalness, industrial biotechnology is transforming the cosmetics industry by offering sustainable and innovative alternatives to conventional ingredients and processes. It enables the production of valuable active ingredients using microorganisms or enzymes, while improving their performance, naturalness, and traceability.

TWB supports these developments through its multidisciplinary approach covering the entire value chain.

Producing bio-based active ingredients as alternatives to natural extracts or petrochemical ingredients
Improving the stability, functionality, and bioavailability of cosmetic actives
Optimizing the fermentation of a natural ingredient at a competitive cost
Securing the supply of sensitive ingredients and reducing the environmental impact of supply chains
Replacing controversial chemical substances with biological solutions

Health

Industrial biotechnology contributes to the development of innovative solutions for healthcare. It enables the production of therapeutic biomolecules and active ingredients through manufacturing pathways that support safe, controlled, and reproducible processes.

TWB therefore supports innovation in healthcare, from concept to proof of feasibility, and mobilizes its platforms to accelerate the development and scale-up of innovative solutions that strengthen French bioproduction sovereignty and healthcare innovation.

Producing complex therapeutic molecules
Developing biomarkers for diagnostics
Supporting sovereignty in therapeutic bioproduction

Nutrition

Today, industrial biotechnology is innovating in the production of food and nutritional ingredients, improving the functionality, safety, and traceability of products.

TWB supports the development of strains, processes, and pilot-scale production tailored to the needs of the sector.

Improving properties (taste, stability, bioactivity) through fermentation
Developing bio-based ingredients to help increase livestock productivity
Contributing to the security of food supply chains through new traceability markers
Producing bio-based dietary supplements for the nutraceutical sector

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Energy

The production of renewable energy is at the heart of addressing humanity’s impact on the environment. Industrial biotechnology makes it possible to convert biomass into biofuels and energy molecules. These processes help reduce dependence on fossil resources.

TWB works on optimizing strains and processes to improve yields and industrial viability.
In doing so, it actively contributes to the energy transition.

Treating or valorizing industrial effluents and organic waste as energy
Optimizing industrial bioprocesses to reduce the carbon footprint using microorganisms or enzymes

Agriculture and Environment

Industrial biotechnology provides sustainable solutions for agriculture and soil health. By developing biofertilizers, biostimulants, and biocontrol solutions, these approaches help reduce the use of chemical inputs and the environmental and health impacts of agricultural practices, within a “One Health” approach. They therefore support the development of more sustainable and resilient agricultural systems.

TWB supports the design and optimization of microorganisms and processes tailored to agricultural applications.

Producing peptides intended for biocontrol
Driving the natural evolution of microorganisms that provide ecosystem services in soils

Accelerate Your Innovation Project

Whether you’re a startup, a manufacturing company, an SME, or a research lab…
We’re here to help you tackle your biggest challenges.