Fermentation Platform
TWB’s fermentation platform provides a fleet of instrumented bioreactors dedicated to the development, optimization, and scale-up of biotechnological processes, from screening at the mL scale through to the pre-pilot stage (300 L in collaboration with CRITT Bio-Industries).
Performance
and Innovation
The integration of online and offline analytical systems enables detailed, multiparametric characterization of the liquid, solid, and gaseous phases.
This approach provides dynamic monitoring of cultures and facilitates the study, understanding, and optimization of fermentations based on enzymatic or microbial processes.
Scaling down processes using miniaturized, parallelizable, and robust devices makes it possible to:
- to speed up experimental cycles,
- to significantly increase the analysis throughput,
- to ensure the safety of critical stages in process development.
This integrated organization serves as a strategic tool for reducing technical risks during the scale-up phases and improving the predictability of performance at a larger scale.
Areas of Specialization and Expertise
+30
different types of
microorganisms used
Bacteria, yeasts, filamentous fungi, and amoebae,
more than half of which are non-traditional organizations
Recognized expertise in adapting processes to a variety of biological models and in harnessing the potential of atypical microorganisms with high biotechnological potential.
- Screening and optimization of culture conditions (bacteria, yeasts, fungi, etc.)
- Scale-up of aerobic or anaerobic bioprocesses and preparation of process books
- Directed evolution, strain adaptation, and improvement of production yields
- Expertise in fermentation processes and removal of technological barriers
Dispositifs expérimentaux
- Batch, fed-batch, and continuous fermentation
- Directed Evolution System (Adaptive Laboratory Evolution)
- Culture and Fermentation: From Screening to Scaling Up
- Aerobic and Anaerobic
- Screening and microculture (1 mL)
- Online Monitoring of Biomass, pH, and pO₂
- High-throughput approach for strain screening and optimization of culture conditions
- Scale-up and batch production system (1 mL to 300 L)
- 20-liter and 300-liter pre-pilot fermenters (in collaboration with CRITT Bio-Industries)
- Real-time sensors and offline monitoring of fermentation processes using chemical analysis and cytometry
Access and Support
Access to the platform comes with scientific and technical support, including:
- training in the use of certain equipment,
- the provision of experimental tools,
- and tailored follow-up based on the contractual framework (service provision, R&D collaboration, or public-private partnership).
